2. To produce an appropriate physical effect; to issue in the
result designed by nature; especially (Med.), to take
appropriate effect on the human system.
3. To act or produce effect on the mind; to exert moral power
or influence.
The virtues of private persons operate but on a few.
--Atterbury.
A plain, convincing reason operates on the mind both
of a learned and ignorant hearer as long as they
live. --Swift.
4. (Surg.) To perform some manual act upon a human body in a
methodical manner, and usually with instruments, with a
view to restore soundness or health, as in amputation,
lithotomy, etc.
5. To deal in stocks or any commodity with a view to
speculative profits. [Brokers' Cant]